Actin released into extracellular space during wounding can become toxic in the bloodstream. The actin scavenging system involves gelsolin breaking down F-actin so that it can be cleared, preventing actin toxicity. However, another protein commonly found in wounds, Flightless I, is thought to interfere with the scavenging system.
We are developing mathematical models for the F-actin length distribution and kinetic parameters for the interactions between F-actin, gelsolin, and Flii. We infer model parameters based on actin dynamics experiments performed in UniSA’s Future Industries Institute (FII).
The presence of bacterial biofilms in wounds can lead to persistent infections and impaired healing. Experimental researchers in FII have developed a smart hydrogel for targeted delivery of antimicrobial agents to wounds.
We are developing mathematical models for the delivery of antimicrobials, using agent-based and continuum mechanical approaches.
Watch this space!